Orals-Tamoxifen Citrate (Nolvadex)- 10mg * 100Tablets

Active Ingredients: Tamoxifen Citrate 10mg
Tablet Count: 100 Tabs
Protein Binding: 99%
Concentration: 10 mg/tab
Presentation: 100 Tabs
Trade Name: Nolvadex, Genox, Tamoxifen, Other

This item: Orals-Tamoxifen Citrate (Nolvadex)- 10mg * 100Tablets

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Nolvadex (Tamoxifen Citrate) is an oral medication used for various purposes related to breast health. Let’s explore the details:

  1. Active Ingredient: Tamoxifen citrate
  2. Brand/Trade Name: Nolvadex
  3. Chemical Structure:
    • Chemical Formula: C26H29NO
    • Molecular Weight: 371.51 g/mol
    • Structural Representation: !Tamoxifen citrate
  4. Description:
    • Nolvadex (tamoxifen citrate) is a white to off-white crystalline powder.
    • It is freely soluble in methanolsoluble in ethanolslightly soluble in acetonewater, and chloroform, and insoluble in ether.
    • Each white scored tablet contains 10 mg tamoxifen citrate USP.
    • Inactive ingredients include corn starch, lactose, magnesium stearate, pregelatinized cornstarch, and sucrose.
  5. Clinical Pharmacology:
    • Tamoxifen citrate is a nonsteroidal antiestrogen.
    • It interacts with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix.
    • Tamoxifen may compete with estrogen for binding sites and delay replenishment of intracellular estrogen receptors.
    • It initiates a series of endocrine events, leading to a preovulatory gonadotropin surge and subsequent follicular rupture.
    • The drug has both estrogenic and antiestrogenic effects.
    • It does not have apparent progestational, androgenic, or antiandrogenic effects.
    • Spontaneous ovulatory menses have been noted in some patients after Nolvadex therapy.
  6. Indications:
    • Breast Cancer Treatment: Used to treat metastatic breast cancer and reduce the risk of breast cancer in high-risk patients.
    • Post-Surgery and Radiation: Administered after surgery and radiation therapy.
  7. Contraindications:
    • Avoid Nolvadex in patients with ovarian cysts or enlargement not due to polycystic ovarian syndrome.