Clomifene (Clomid) is an orally administered, nonsteroidal ovulatory stimulant. Let’s delve into the details:

1. Active Ingredient: Clomifene citrate
2. Brand/Trade Name: Clomid
3. Chemical Structure:
   • Chemical Formula: C26H28ClNO • C6H8O7
   • Molecular Weight: 598.09 g/mol
   • Structural Representation: !Clomiphene citrate
4. Description:
   • Clomifene citrate is a white to pale yellow, essentially odorless, crystalline powder.
   • It is freely soluble in methanol, soluble in ethanol, slightly soluble in acetone, water, and chloroform, and insoluble in ether.
   • Each white scored tablet contains 50 mg clomiphene citrate USP.
   • Inactive ingredients include corn starch, lactose, magnesium stearate, pregelatinized cornstarch, and sucrose.
5. Clinical Pharmacology:
   • Clomifene citrate interacts with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix.
   • It competes with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracellular estrogen receptors.
   • Clomifene citrate initiates a series of endocrine events, leading to a preovulatory gonadotropin surge and subsequent follicular rupture.
   • The two clomiphene isomers (zuclomiphene and enclomiphene) have mixed estrogenic and antiestrogenic effects.
   • Clomifene does not have apparent progestational, androgenic, or antiandrogenic effects.
   • Spontaneous ovulatory menses have been noted in some patients after Clomid therapy.
6. Indications:
   • Clomid is used for increasing muscle mass and muscle strength.
   • It enhances nitrogen retention, protein synthesis, muscle building, cell repair, and metabolism.
   • Clomid is favored by powerlifters due to its strength gains.
   • It may increase aggression during intense workouts.